Dear Colleagues,

Diabetic retinopathy (DR) continues to present significant challenges despite recent advancements in its diagnostics and treatments. As the global burden of diabetes grows, effective prevention and management of diabetic blindness remain at the forefront of ophthalmic research. In the Sep/Oct issue of APJO, we published a perspective article by Prof. Tien Yin Wong and his team on the latest developments aimed at combating diabetic eye disease, anchored by our editorial, which emphasizes that diabetic blindness remains a substantial challenge despite recent innovations.

Moreover, we have a study describing the effects of childhood atropine treatment on adult choroidal thickness, revealing that early exposure to atropine is associated with a thicker choroid in adulthood. This finding may have significant implications for understanding ocular health as patients age.

Additionally, public health concerns are further addressed in a real-world assessment of drug-related dry eye risk, which leverages data from the FDA adverse event reporting system. This study sheds light on the prevalence of drug-induced dry eye, a condition affecting millions of patients globally, emphasizing the need for improved pharmacovigilance.

Other publications include 1) Long-term outcomes of combined phacotrabeculectomy in a Singapore tertiary hospital; 2) Accuracy of large language models in answering ophthalmology board-style questions; 3) Development of an AI-based mobile app to reduce cataract backlogs in Uttar Pradesh, India; 4) Acute macular neuroretinopathy related to the COVID-19 pandemic; 5) Challenges in managing inherited retinal diseases across the Asia-Pacific: A survey from the APIED network; 6) Advances in IgG4-related ophthalmic disease; and 7) Chromosome 8q gain and high EZH2 expression as predictors of poor prognosis in Chinese uveal melanoma patients.

Please find below the full list of articles in this issue of APJO:

APJO SEP/OCT GENERAL ISSUE

•	Diabetic Blindness Remains a Big Challenge Despite All Recent Advancements in Diagnostics and Treatments (Editorial)
	Jingfa Zhang*, Min Wang, Ling Chen, Nishant Radke
•	Current Research and Future Strategies to Reduce Diabetic Blindness (Perspective)
	Huating Li, Weiping Jia, Stela Vujosevic, Charumathi Sabanayagam, Jakob Grauslund, Sobha Sivaprasad, Tien Yin Wong*
•	Effect of Childhood Atropine Treatment on Adult Choroidal Thickness Using Sequential Deep Learning Enabled Segmentation (Original Study)
	Yong Li, Damon Wong, Syna Sreng, Joey Chung, Angeline Toh, Han Yuan, Leila Sara Eppenberger, Cheryl Leow, Daniel Ting, Nan Liu, Leopold Schmetterer, Seang-Mei Saw, Jost B. Jonas, Audrey Chia, Marcus Ang*
•	Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network (Original Study)
	Wendy Wong, Yih Chung Tham, Lauren N. Ayton, Alexis Ceecee Britten-Jones, Thomas L. Edwards, John Grigg, Matthew P. Simunovic, Fred K. Chen, Zi-Bing Jin, Ren-Juan Shen, Ruifang Sui, Liping Yang, Chen Zhao, Haoyu Chen, Shiying Li, Xiaoyan Ding, Muna Bhende, Rajiv Raman, Parveen Sen, B Poornachandra, Valen Chia, Florence Manurung, Muhammad Bayu Sasongko, Hanako Ikeda, Kaoru Fujinami, Se Joon Woo, Sang Jin Kim, Mae-Lynn Catherine Bastion, Ain Tengku Kamalden, Penny P Lott, Kenneth Fong, Manoharan Shunmugam, Amelia Lim, Raba Thapa, B Manuel Benjamin IV Ibañez, Adrian Koh, Graham E Holder, Xinyi Su, Choi Mun Chan, Beau J Fenner, Augustinus Laude, Wei Kiong Ngo, Ta-Ching Chen, Nan-Kai Wang, Eugene Yu-Chuan Kang, Nuntachai Surawatsatien, Phattrawan Pisuchpen, Tharikarn Suijirakul, Nida Wongchaisuwat, Atitaya Apivatthakakul, Govindasamy Kumaramanickavel, Bart Leroy, Michel Michaelides, Nikolas Pontikos, Ching-Yu Cheng, Chi Pui Pang, Li Jia Chen, Hwei Wuen Chan*
•	Real-World Large Sample Assessment of Drug-related Dry Eye Risk: Based on the FDA Adverse Event Reporting System Database (Original Study)
	Shi-Nan Wu, Caihong Huang, Yu-Qian Wang, Xiao-Dong Chen, Xiang Li, Si-Qi Zhang, Dan-Yi Qin, Linfangzi Zhu, Chang-Sheng Xu, Qing-He Zhang, Jiaoyue Hu, Zuguo Liu
•	Acute Macular Neuroretinopathy Associated with COVID-19 Pandemic: A Real-world Observation Study (Original Study)
	Xiaojia Song, Yajie Yu, Haiying Zhou, Yongpeng Zhang, Yu Mao, Hong Wang, Xusheng Cao, Xiaoqing Zhu, Zhihua Li, Lin Li, Jinghua Liu, Xiaoyan Peng, Qian Li
•	Long-Term Outcomes of Combined Phacotrabeculectomy Surgery in a Singapore Tertiary Hospital (Original Study)
	Annabel CY Chew, Hla Myint Htoon, Shamira A Perera, Tin Aung, Ho Ching Lin, Rahat Husain, Pui Yi Boey, Daniel Hsien Wen Su, Jocelyn Chua, Tina T. Wong*
•	Accuracy of Large Language Models in Answering Ophthalmology Board-style Questions: A Meta-analysis (Review Article)
	Jo-Hsuan Wu, Takashi Nishida, T.Y Alvin Liu*
•	Development and Testing of Artificial Intelligence-Based Mobile Application to Achieve Cataract Backlog-free Status in Uttar Pradesh, India (Original Study)
	Madhavi Devaraj, Vasanthakumar Namasivayam, Satya Swarup Srichandan, Eshan Sharma, Apjit Kaur, Nibha Mishra, Dev Vimal Seth, Akanksha Singh, Pankaj Saxena, Eshaan Vasanthakumar, James Blanchard, Ravi Prakash
•	Advances in Understanding and Management of IgG4-related Ophthalmic Disease (Review Article)
	Kenneth Ka Hei Lai, Terence Wee Xiang Ang, Wah Cheuk, Angie Kwok, Ming Lin, Yael Lustig, Dinesh Selva, Guy Ben Simon, Yue Xing, Zhi Hui Xu, Hua Sheng Yang, Kelvin Kam Lung Chong, Hunter Kwok Lai Yuen
•	Gain of chromosome 8q and high expression of EZH2 may predict poor prognosis in Chinese patients with uveal melanoma (Original Study)
	Lingyu Zhang, Hui Pan, Yiran Yao, Xiang Gu, Tongxin Ge, Junqi Cui, Peiwei Chai, Xiaofang Xu, Renbing Jia, Ai Zhuang, Xianqun Fan*

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